Thursday 26 January 2006

ConjuChem Announces Fiscal 2005 Year-End Financial Results

MONTREAL, Jan. 26 - ConjuChem Inc. (TSX:CJC) today announced
financial results for its fiscal year, ended October 31, 2005.
    "2005 was highlighted by the development of our new PC-DAC(TM)
technology, which is a natural extension of our albumin bonding expertise and
intellectual property," said Lennie Ryer, Chief Financial Officer. "We believe
strongly in the power of PC-DAC(TM) to unlock the therapeutic potential of
peptides. In 2006, we will endeavour to advance this technology in multiple
programs."
    The Company's net loss for the year ended October 31, 2005 was
$38.5 million or ($0.83) per share, compared to $47.7 million or ($1.13) per
share, for the year ended October 31, 2004. The decrease in the net loss is
mainly attributable to a decrease in net research and development expenses of
$13.7 million.
    The Company recorded interest income on cash and short-term investments
of $623,389 for the year versus $812,814 in the same period last year. The
decrease in interest revenue was a result of a reduced investment base in our
portfolio.
    Net research and development expenses amounted to $23.9 million for the
year ended October 31, 2005, compared with $37.6 million for the year ended
October 31, 2004. The decrease in these costs is primarily attributable to
reduced costs of the clinical development programs for DAC(TM):GLP-1 and
DAC(TM):GRF compared to the prior fiscal year.
    General and administrative costs for the year ended October 31, 2005
amounted to $4.5 million compared to $5.0 million for the same period last
year. The decrease in expenses is the result of cost control implementation in
numerous areas of our operation.
    At October 31, 2005, the Company had cash and cash equivalents of
$17.8 million and a working capital position of $14.6 million. These funds are
sufficient to meet all of our current obligations and are sufficient to meet
our committed expenditures into 2006.

    Outlook
    The Company's development priorities for 2006 will focus on advancing our
clinical programs. We intend to complete the Phase I program on our lead
diabetes compound PC-DAC(TM) Exendin-4. This will enable the Company to build
the data base to satisfy regulatory requirements which would support the
commencement of a Phase II program for this compound. We also anticipate
securing a partnership agreement with a leading pharmaceutical company to
optimize the commercial value of this compound.
    The Company also plans to complete in 2006 its initial Phase II clinical
trial with DAC(TM):GRF for the treatment of Lipodystrophy in HIV patients.

    About ConjuChem
    ConjuChem, developers of next generation medicines from therapeutic
peptides, is creating long-acting compounds based on bioconjugation platform
technologies. When applied to peptides, the Company's systemic DAC(TM) and 
PC-DAC(TM) Technologies enable the creation of new drugs with significantly
enhanced therapeutic properties as compared to the original peptide. The
Company is developing compounds to treat various disorders including diabetes,
human growth deficiencies, HIV/AIDS, and congestive heart failure.
    Detailed descriptions of the Company can be viewed on the Company's
website www.conjuchem.com.

    Financial statements included below.


    <<
                               BALANCE SHEETS

    As at October 31

                                                         2005           2004
                                                            $              $
    -------------------------------------------------------------------------

    ASSETS
    Current
    Cash and cash equivalents                         137,218      2,707,382
    Short-term investments                         17,708,732     24,087,983
    Accounts receivable                               331,174        412,489
    Investment tax credits recoverable                450,000        551,000
    Prepaids                                          280,029        193,987
    -------------------------------------------------------------------------
    Total current assets                           18,907,153     27,952,841
    Deferred financing fees                           109,563        144,451
    Property, plant and equipment                   1,327,200      1,394,469
    Intangible assets                                  66,136         83,132
    -------------------------------------------------------------------------
                                                   20,410,052     29,574,893
    -------------------------------------------------------------------------
    -------------------------------------------------------------------------

    LIABILITIES AND SHAREHOLDERS' DEFICIENCY
    Current liabilities
    Accounts payable and accrued liabilities        4,318,493      5,780,305
    -------------------------------------------------------------------------
    Total current liabilities                       4,318,493      5,780,305
    -------------------------------------------------------------------------
    Convertible senior unsecured notes             39,183,820     34,047,344
    -------------------------------------------------------------------------
                                                   43,502,313     39,827,649
    -------------------------------------------------------------------------

    Shareholders' deficiency
    Capital stock                                 147,169,448    125,530,006
    Warrants                                        3,276,000      3,276,000
    Equity portion of convertible senior
     unsecured notes                               14,966,780     14,966,780
    Contributed surplus                            12,413,577      3,031,336
    Deficit                                      (200,918,066)  (157,056,878)
    -------------------------------------------------------------------------
    Total shareholders' deficiency                (23,092,261)   (10,252,756)
    -------------------------------------------------------------------------
                                                   20,410,052     29,574,893
    -------------------------------------------------------------------------
    -------------------------------------------------------------------------

 

                    STATEMENTS OF OPERATIONS AND DEFICIT

    Year ended October 31,

                                                         2005           2004
                                                            $              $
    -------------------------------------------------------------------------

    REVENUES
    Contract revenue                                   82,318          7,635
    Interest income                                   623,389        812,814
    -------------------------------------------------------------------------
                                                      705,707        820,449
    -------------------------------------------------------------------------

    EXPENSES
    Research and development                       25,962,694     38,442,896
    Investment tax credits                         (2,025,233)      (807,681)
    -------------------------------------------------------------------------
    Net research and development expenses          23,937,461     37,635,215
    General and administrative expenses             4,486,134      4,959,026
    Amortization of property, plant and equipment     340,950        399,973
    Amortization of intangible assets                  49,756         63,699
    Amortization of deferred financing fees            34,888         25,914
    Non-cash stock based compensation               5,178,167      2,250,462
    Financial charges                                  16,610         23,853
    Foreign exchange loss                              43,000         22,256
    Accretion in carrying value of convertible
     senior unsecured notes                         5,136,476      3,099,090
    -------------------------------------------------------------------------
                                                   39,223,442     48,479,488
    -------------------------------------------------------------------------
    Net loss                                      (38,517,735)   (47,659,039)
    -------------------------------------------------------------------------
    Deficit, beginning of year                   (157,056,878)  (109,397,839)
    -------------------------------------------------------------------------
    Transitional adjustment for stock based
     compensation                                  (5,343,453)             -
    Deficit, end of year                         (200,918,066)  (157,056,878)
    -------------------------------------------------------------------------
    -------------------------------------------------------------------------

    Basic and diluted loss per share                    (0.83)         (1.13)
    -------------------------------------------------------------------------
    -------------------------------------------------------------------------

    Weighted average number of common shares       46,239,541     42,316,171
    -------------------------------------------------------------------------
    -------------------------------------------------------------------------

 

                          STATEMENTS OF CASH FLOWS

    Year ended October 31,

                                                         2005           2004
                                                            $              $
    -------------------------------------------------------------------------

    OPERATING ACTIVITIES
    Net loss                                      (38,517,735)   (47,659,039)
    Items not affecting cash:
    Amortization of property, plant and equipment     340,950        399,973
    Amortization of intangible assets                  49,756         63,699
    Amortization of deferred financing fees            34,888         25,914
    Amortization of premium on investments              5,466         59,910
    Non-cash stock based compensation               5,178,167      2,250,462
    Accretion in value of convertible senior
     unsecured notes                                5,136,476      3,099,090
    -------------------------------------------------------------------------
                                                  (27,772,032)   (41,759,991)
    Net changes in non cash working capital
     balances relating to operations               (1,365,539)     2,247,762
    -------------------------------------------------------------------------
    Cash flows relating to operating activities   (29,137,571)   (39,512,229)
    -------------------------------------------------------------------------

    INVESTING ACTIVITIES
    Acquisition of short-term investments         (30,175,880)   (53,708,836)
    Proceeds on maturities of short-term
     investments                                   36,549,665     71,092,786
    Acquisition of property, plant and equipment     (273,681)      (124,665)
    Acquisition of intangible assets                  (32,760)       (38,865)
    Proceeds on maturities of long-term investments         -      3,409,875
    -------------------------------------------------------------------------
    Cash flows relating to investing activities     6,067,344     20,630,295
    -------------------------------------------------------------------------

    FINANCING ACTIVITIES
    Issuance of common shares for cash             21,874,245      6,503,516
    Share issue costs paid in cash                 (1,374,182)      (182,590)
    Issuance of convertible senior unsecured notes          -     15,000,000
    Issue costs of convertible senior unsecured
     notes                                                  -       (102,017)
    -------------------------------------------------------------------------
    Cash flows relating to financing activities    20,500,063     21,218,909
    -------------------------------------------------------------------------

    Net increase (decrease) in cash and cash
     equivalents during the year                   (2,570,164)     2,336,975
    Cash and cash equivalents, beginning of year    2,707,382        370,407
    -------------------------------------------------------------------------
    Cash and cash equivalents, end of year            137,218      2,707,382
    -------------------------------------------------------------------------
    -------------------------------------------------------------------------

    Supplemental cash flow information:
    Cash paid during the year for:
    Interest                                            5,827         12,063
    -------------------------------------------------------------------------