Glossary
Glossary
- Albumin
- a class of simple, water-soluble proteins that are the main component of blood. Albumin is a constituent in a majority of all blood proteins and is circulated throughout nearly all tissues and organs in the body via the blood.
- Analog
- a compound resembling another in structure, but one that is not necessarily an isomer.
- Bioconjugation
- the irreversible bonding of the biologic and chemical activities of two or more compounds, resulting in a final compound composed of attributes from all original compounds.
- Covalent Bond
- a chemical bond formed by the sharing of one or more electrons between atoms which creates a force that holds the atoms together.
- Drug Affinity Complex (DAC™)
- a ConjuChem-developed technology that features a synthetic modification of a well characterized peptide moiety and yet retains most of its original biologic activity.
- Ex vivo
- outside of the body.
- Exendin-4
- a glucagon-like peptide-1 (GLP-1) homolog and an analog for the GLP-1 receptor that lowers blood glucose levels through a distinct mechanism complementary to the mechanism of currently available antidiabetic drugs.
- GLP-1
- glucagun-like peptide-1, a synthesized peptide used to stimulate production of glucose-dependent insulin and insulin biosynthesis, inhibit glucagon secretion and gastric emptying, and inhibition of food intake.
- Half-life
- the amount of time required for one half of an amount of a substance to be lost through biologic processes.
- Homolog
- a member of a pair corresponding or alike in certain critical attributes.
- In vitro
- in an artificial environment outside of the living organism.
- In vivo
- in nature or within a living organism.
- Lipodystrophy
- a metabolic syndrome characterized by glucose intolerance and changes in distribution of adipose (fat-containing) tissue.
- Peptidase Degradation
- the process of an enzyme catalyzing the splitting of proteins into smaller peptides and amino acids.
- Peptide
- a compound of two or more amino acids linked by the carboxyl group of one amino acid to the amino group of the other amino acid. A long chain of peptides is known as a protein.
- Preformed Conjugate – Drug Affinity Complex (PC-DAC™)
- a natural extension of the core DAC™ technology in which peptides are engineered to attach covalently to albumin outside the body.
- Recombinant
- an offspring having a non-parental allele combination; an individual or cell with a genotype produced by recombination.
- Subcutaneous
- located or placed just beneath the skin.
- Synthesize
- to form something new by the union of simpler compounds or elements.
- T-cells
- a subset of lymphocytes playing a larger role in immune response, produced in the thymus.
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